Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia
Ian Hunter Guldner, Viktoria Wagner, Patricia Morán Losada, Sophia M. Shi, Kelly S. Chen, Barbara T Meese, Hamilton Se‐Hwee Oh, Yann Le Guen, Nannan Lu, Pui Shuen Wong, Ning-Sum To, Dylan T. Garceau, Zimin Guo, Jian Luo, Michael Sasner, , Tony Wyss‐Coray
The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.
bioRxiv · May 20, 2025 · PreprintNeuroscience