Tali Shalit

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

The paper models a macrophage-myofibroblast circuit to predict fibrosis types and shows targeting the myofibroblast autocrine loop reduces fibrosis after myocardial infarction.

The paper presents a spatial RNA editing map in the Drosophila brain, revealing distinct editing signatures across neuronal populations and identifying novel editing sites in conserved regions of essential neuronal genes.