Epithelial MHC II antigen presentation dynamically informs intestinal homeostasis and injury
V. V. Holiar, Vladislav Rudenko, Chen Weller, Mariia Naumova, Sacha Lebon, Marco Canella, Petro Busko, Avital Sarusi-Portuguez, Tali Shalit, Aviya Habshush Menachem, Idan Adir, Zachary Petrover, Polina Greenberg, Corine Katina, Polina Gradchenko, , Moshe Biton
This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.
bioRxiv · Mar 20, 2026 · PreprintImmunology