Sarah E. Maguire

The paper uses spatial transcriptomics to analyze molecular differences in mood disorders and biological sex in the human prefrontal cortex, identifying sex- and disorder-specific gene expression patterns.

This study maps the spatiomolecular organization of the human habenula using multi-omic approaches, identifying molecular signatures and spatial domains linked to psychiatric disorders.

This paper develops a 3D spatial genomics framework to reconstruct the molecular and cellular organization of the human nucleus accumbens across anatomical axes.

This study creates a spatial transcriptomic atlas of the human amygdala, revealing distinct cell types and genetic risk localization across its subnuclei.

This study creates a spatiomolecular atlas of the human nucleus accumbens using spatial transcriptomics and single-nucleus RNA sequencing, revealing spatial gradients and conserved features across species.

This study maps molecular and genetic signatures of schizophrenia in human prefrontal cortex across spatial scales, revealing altered BDNF-TrkB signaling and inhibitory circuit dysfunction.

spaTransfer transfers cell type or spatial domain labels between single-cell and spatial transcriptomics datasets using non-negative matrix factorization and a multinomial model.

The paper analyzes the transcriptomic landscape of the human locus coeruleus in relation to Alzheimer's disease risk factors and neuromelanin content using spatially-resolved transcriptomics.

The paper shows that in Anopheles gambiae, ectopic expression of an odorant receptor (AgOr2) in ORNs dampens neuronal activity and downregulates endogenous Or transcripts, unlike Drosophila where ectopic ORs do not interfere with native physiology.

This paper introduces olfactogenetics to specifically activate olfactory neurons in Drosophila and identifies neuron types and brain regions involved in suppressing oviposition.