Author

Luis F. Caldera

California Institute of TechnologyORCID 0009-0005-3254-6563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Jennifer R. KeeffeiD· 2 shared Pamela J. BjörkmaniD· 2 shared Priyanthi N.P. GnanapragasamiD· 2 shared Adrian J. Bahn-SuhiD· 1 shared Alexander A. CoheniD· 1 shared Annie V. RorickiD· 1 shared Arup K. ChakrabortyiD· 1 shared Eric Ji Da WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Jennifer R. KeeffeORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintMar 27, 2026

Stabilized gp120-specific CD4 for next-generation HIV-1 inhibitors

Adrian J. Bahn-Suh, Luis F. Caldera, Priyanthi N.P. Gnanapragasam…·Stephen L. Mayo

This paper develops a gp120-specific CD4 variant (gCD4) that improves thermostability, reduces off-target class II MHC binding, and enhances HIV-1 neutralization compared to existing CD4-Ig biologics.

DOI 10.64898/2026.03.24.713825

humanproteomics

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ImmunologyCellPeer-reviewedJan 23, 2025

Designed mosaic nanoparticles enhance cross-reactive immune responses in mice

Eric Ji Da Wang, Alexander A. Cohen, Luis F. Caldera…·Arup K. Chakraborty

The paper designs mosaic nanoparticles with SARS-like betacoronavirus RBDs to enhance cross-reactive immune responses in mice, finding that mosaic-7COM elicits stronger responses against zoonotic sarbecoviruses and Omicrons.

30 citationstop 1%

mouseexperimental assay

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