NeurosciencebioRxivPreprint
Kappa opioid receptors regulate cocaine effects on nucleus accumbens dopamine through phosphorylation of dopamine transporter at the threonine 53 site
Emanuel F. Lopes, Paige M. Estave, Alyson M. Curry…·Sara R. Jones
This study shows that KOR activation leads to DAT tolerance to cocaine via phosphorylation at threonine 53, demonstrated through behavioral, electrophysiological, and genetic experiments across species.