Sara R. Jones

Kappa opioid receptors regulate cocaine effects on nucleus accumbens dopamine through phosphorylation of dopamine transporter at the threonine 53 site

This study shows that KOR activation leads to DAT tolerance to cocaine via phosphorylation at threonine 53, demonstrated through behavioral, electrophysiological, and genetic experiments across species.

Kappa opioid receptors delay sucrose self-administration by modulating dopamine ramps before operant responding

This study shows that KOR activation delays sucrose self-administration by reducing dopamine ramps before lever pressing in mice.

Fiber photometry analysis for spontaneous dopamine signals: The z-scored data are not the data

The paper compares three methods for analyzing spontaneous dopamine signals and finds that z-scoring is unreliable, while manual and prominence methods are more accurate.

Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategies

This study creates a mouse model of DTDS with the A313V DAT variant and identifies two potential treatments, [a]MPT and AMPH, that reduce hyperactivity.

Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking

The paper examines how chronic alcohol drinking affects the relationship between gene expression and dopamine regulation in the brain, finding persistent functional changes despite no change in transcript levels.

Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits

This study shows that synaptogyrin-3 reduces cocaine self-administration and prevents dopamine deficits by enhancing dopamine signaling and cognitive flexibility in rats.

Kappa Opioid Receptors Negatively Regulate Real Time Spontaneous Dopamine Signals by Reducing Release and Increasing Uptake

This study shows that KOR activation reduces dopamine release and increases uptake, leading to decreased spontaneous dopamine signals in both male and female mice.

Nicotine Modifies Responding for Cocaine in a Concurrent Rodent Self-administration Model

This study examines how adding nicotine to cocaine self-administration in rats affects behavior under different reinforcement schedules, finding reduced responding under long access but increased responding under progressive ratio conditions.

Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration

This study investigates the effects of intermittent nicotine self-administration in rats, finding increased nicotine seeking and neurobiological changes compared to continuous access.

Heroin Self-Administration Induces Altered Dopamine Terminal Dynamics in the Nucleus Accumbens

This study shows that chronic heroin self-administration reduces basal dopamine levels and alters dopamine release dynamics in the nucleus accumbens, potentially contributing to increased heroin seeking.

Stress-induced alterations of norepinephrine release in the bed nucleus of the stria terminalis of mice

The paper examines how repeated stress affects norepinephrine release in the BNST of mice, finding increased release and reduced autoreceptor sensitivity.