Author

Emanuel F. Lopes

University of OxfordORCID 0000-0003-1426-8350Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:electronic health records· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:rat· 1

Frequent Co-Authors

Bradley M. RobertsiD· 2 shared Katherine M. HolleraniD· 2 shared Katherine R. BrimblecombeiD· 2 shared Nora Bengoa‐VergnioryiD· 2 shared Sara R. JonesiD· 2 shared Stephanie Jane CraggiD· 2 shared Adam Loyd HarrisiD· 1 shared Alyson M. CurryiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Bradley M. RobertsORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 21, 2026

Kappa opioid receptors regulate cocaine effects on nucleus accumbens dopamine through phosphorylation of dopamine transporter at the threonine 53 site

Emanuel F. Lopes, Paige M. Estave, Alyson M. Curry…·Sara R. Jones

This study shows that KOR activation leads to DAT tolerance to cocaine via phosphorylation at threonine 53, demonstrated through behavioral, electrophysiological, and genetic experiments across species.

DOI 10.64898/2026.05.06.722744

ratmouse

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 23, 2025

Kappa opioid receptors delay sucrose self-administration by modulating dopamine ramps before operant responding

Conner W. Wallace, Emanuel F. Lopes, Katherine M. Holleran, Sara R. Jones

This study shows that KOR activation delays sucrose self-administration by reducing dopamine ramps before lever pressing in mice.

DOI 10.1101/2025.10.23.684229

mouseelectronic health records

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 16, 2025

Gabapentinoids promote striatal dopamine release and rescue multiple deficits of a mouse model of early Parkinson's

Katherine R. Brimblecombe, Adam Loyd Harris, Nora Bengoa‐Vergniory…·Stephanie Jane Cragg

This study shows gabapentinoids enhance dopamine release in a Parkinson's mouse model and improve movement deficits by modulating calcium and GABAergic signaling.

DOI 10.1101/2025.09.16.675586

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 7, 2020

Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism

Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe…·Stephanie Jane Cragg

The paper investigates the role of astrocytic GABA transporters in regulating dopamine release in the striatum and shows their downregulation in early parkinsonism.

1 citation

mouseexperimental assay

𝕏 PostBluesky