PhysiologybioRxivPreprint
CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction
Alireza Saadatmand, Mark E. Pepin, Zihao Chen…·Johannes Backs
The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.