Harikrishnareddy Paluvai

Selective class IIa HDAC inhibition reverses diastolic dysfunction in cardiometabolic HFpEF

This study shows that selective class IIa HDAC inhibition improves diastolic dysfunction in HFpEF without adverse effects.

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction

The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsense-mediated mRNA degradation

This study shows that somatic HDAC4-902fs mutations cause loss of HDAC4 function via nonsense-mediated mRNA decay, leading to premature ossification and early death in mice.