CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction
Alireza Saadatmand, Mark E. Pepin, Zihao Chen, Joshua Hartmann, Qiang Sun, Matthias Dewenter, Sumra Nazir, Harikrishnareddy Paluvai, Marco Hagenmüller, Uwe Haberkorn, Lisa Schlicker, Roberto Carlos Frias-Soler, Jens Tyedmers, Christoph Maack, Almut Schulze, Johannes Backs
The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.
bioRxiv · Oct 16, 2025 · PreprintPhysiology