Author

Kyle T Ruark

Harvard UniversityORCID 0009-0005-8900-2348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

David J. MooneyiD· 2 shared Andrew LuiD· 1 shared Andrew S. KhaliliD· 1 shared Ann Gao· 1 shared Azeem ShardaiD· 1 shared Blake F. HananiD· 1 shared Bogdan BudnikiD· 1 shared Christina M. TringidesiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

David J. MooneyORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintJul 24, 2026

Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function

Favour Omafuvwe Obuseh, Michelle Chang, Joshua Price…·David J. Mooney

This study shows that matrix viscoelasticity influences γδ T-cell phenotype and function, with slow-relaxing matrices enhancing cytotoxic programs and tumor control.

1 citation

humanproteomics

𝕏 PostBluesky

BioengineeringAdvanced Healthcare MaterialsPeer-reviewedJan 4, 2026

Human progenitor T-cell differentiation regulated by the mechanical resistance of thymus-mimetic extracellular matrices

Nicholas C. Jeffreys, Kyle T Ruark, Joshua M. J. Price…·David J. Mooney

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

7 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky