Nicholas C. Jeffreys

This study shows how mechanical forces and substrate properties enhance T-cell receptor proofreading by delaying decision-making and improving ligand discrimination.

This study investigates the kinetics of de novo bone and bone marrow niche formation using a hybrid click cryogel system, showing that BMP-2 dose, immune status, and sex influence development rates and hematopoietic cell populations.

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.