Christina M. Tringides

The paper introduces hydroMEA, a 3D hydrogel-based microfluidic device that enables real-time electrophysiological measurements of myelinated nerve-on-chip systems using human iPSC-derived neurons and Schwann cells.

This study uses an in vitro platform to show that glioblastoma induces progressive reorganisation of neuronal networks, leading to altered network dynamics and reduced computational capacity.

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

This paper develops an in vitro platform to measure electrophysiological responses of individual human iPSC-derived nociceptors and identifies distinct response profiles and effects of capsaicin.

This paper develops an implantable biohybrid nerve model for synaptic deep brain stimulation, demonstrating in vitro and in vivo functionality for over 22 days.

This study shows that cyclic OKSM expression rejuvenates adult cardiomyocytes in mice with heart failure, improving systolic function without dedifferentiation.