Author

Blake F. Hanan

Harvard UniversityORCID 0000-0003-2944-7503Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Andrew S. KhaliliD· 2 shared David J. MooneyiD· 2 shared Andrew LuiD· 1 shared Ann Gao· 1 shared Antar DrewsiD· 1 shared Azeem ShardaiD· 1 shared Christina M. TringidesiD· 1 shared David T. ScaddeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBioengineering

Andrew S. KhalilORCID

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2 papers

Recent·Most cited

BioengineeringAdvanced Healthcare MaterialsPeer-reviewedJan 4, 2026

Human progenitor T-cell differentiation regulated by the mechanical resistance of thymus-mimetic extracellular matrices

Nicholas C. Jeffreys, Kyle T Ruark, Joshua M. J. Price…·David J. Mooney

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

7 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

BioengineeringbioRxivPreprintOct 17, 2025

Systematic characterization of existing and novel inducible transgenic systems in human pluripotent stem cells after prolonged differentiation

Michael D. Gallagher, Andrew S. Khalil, Qi Liu…·Rudolf Jaenisch

This study evaluates inducible transgenic systems in human pluripotent stem cells and differentiated cells, identifying a small molecule-mediated splicing switch that enables tunable transgene expression without protein tags.

DOI 10.1101/2025.10.17.683097

humanCRISPR screen

𝕏 PostBluesky