Author

Yoshiyasu Tongu

Tohoku UniversityORCID 0009-0005-9085-0563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander TyshkovskiyiD· 2 shared Takaaki AbeiD· 2 shared Tomoko KasaharaiD· 2 shared Vadim N. GladysheviD· 2 shared Adrian MolièreiD· 1 shared Alibek MoldakozhayeviD· 1 shared Anastasiya VladimirovaiD· 1 shared Bohan ZhangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Alexander TyshkovskiyORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintApr 18, 2025

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

Yohei Honkura, Takehiro Suzuki, Ryota Kujirai…·Takaaki Abe

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

DOI 10.1101/2025.04.18.649305

mouseproteomics

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Systems BiologybioRxivPreprintJul 4, 2024

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

Alexander Tyshkovskiy, Daria Kholdina, Kejun Ying…·Vadim N. Gladyshev

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

27 citations

mousebulk RNA-seq

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