Tomoko Kasahara

This paper develops a human vascular model using iPSC-derived cells that mimics vascular aging phenotypes and responds to vasoactive stimuli, showing potential for aging research and drug discovery.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.