Jun Yan

This paper introduces CODEMax and CODEMax(exo+) genome editing systems that enable efficient and precise search-and-replace editing in human cells with reduced off-target effects.

The paper benchmarks a high-efficiency prime editing platform for multiplexed dropout screening of genetic variants, identifying negative growth phenotypes for nonsense mutations and splice-disrupting synonymous mutations.

The paper introduces Repair-seq to study DSB repair by profiling genetic perturbations and identifies dependencies and novel mechanisms in repair pathways.