Eva Cai

This paper develops a nanoparticle platform to target TLR3 agonist to antigen-presenting cells, improving cancer immunotherapy safety and efficacy by reducing systemic toxicity and enhancing tumor targeting.

The paper identifies new ciliary proteins in the developing brain using proteomics and validates their roles in cortical development.

The paper shows that anionic polypeptide coatings on nanoparticles bind to cancer-associated amino acid transporters, enabling targeted drug delivery through electrostatic interactions and transporter clustering.

The paper uses proximity proteomics to identify Git1 as a regulator of Smo signaling in the Hedgehog pathway, showing its role in Grk2 transport and Smo phosphorylation.