Alexander D. Stoneman

This study shows that the outer polyion layer of layer-by-layer nanoparticles affects protein corona formation, which influences their biodistribution and therapeutic efficacy.

This paper develops a nanoparticle platform to target TLR3 agonist to antigen-presenting cells, improving cancer immunotherapy safety and efficacy by reducing systemic toxicity and enhancing tumor targeting.

The paper shows that anionic polypeptide coatings on nanoparticles bind to cancer-associated amino acid transporters, enabling targeted drug delivery through electrostatic interactions and transporter clustering.

The paper describes a method to engineer RNA-based biosensors for mammalian cells using random sequence libraries, demonstrating a biosensor for L-dopa detection.