Mario O. Caracci

The paper investigates how EGF and EREG influence early oncogenic transformation in intestinal organoids by altering crypt and villus development.

This paper develops a reversible Opto-Chemical system to activate KRASG12V signaling with near single-cell precision and demonstrates its effects on epithelial transformation.

This study shows that EGF and EREG ligands regulate proliferation and differentiation in mouse intestinal organoids by modulating EGFR endocytosis and surface expression.

This study identifies ApoER2 as a cargo of the AP-4 complex and shows that AP-4 defects affect its trafficking and Reelin signaling, potentially contributing to Hereditary Spastic Paraplegia.