Luis Manuel Muñoz-Nava

EGF and EREG regulate early oncoprotein-mediated tissue transformation in intestinal organoids.

The paper investigates how EGF and EREG influence early oncogenic transformation in intestinal organoids by altering crypt and villus development.

Reversible Opto-Chemical activation of KRASG12V signaling with near single-cell precision

This paper develops a reversible Opto-Chemical system to activate KRASG12V signaling with near single-cell precision and demonstrates its effects on epithelial transformation.

Proliferation and differentiation in intestinal organoids as a balance of ligand-modulated EGFR trafficking

This study shows that EGF and EREG ligands regulate proliferation and differentiation in mouse intestinal organoids by modulating EGFR endocytosis and surface expression.

Vestigial-dependent recruitment contributes to robust patterning but is not required for wing-fate induction in Drosophila

Interplay between cell proliferation and recruitment controls the duration of growth and final size of the Drosophila wing

The paper develops a mathematical model to show that cell recruitment compensates for variations in cell proliferation rates, ensuring robust wing size in Drosophila.

A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the Vestigial expression pattern

This study shows cell recruitment drives Vg pattern overscaling in Drosophila wing development, leading to wing size reduction when recruitment is impaired.