Author

Melissa R. Leyden

University of VirginiaORCID 0009-0006-4402-5236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

Donald F. HuntiD· 2 shared Jeffrey ShabanowitziD· 2 shared Alexandra SchureriD· 1 shared Benjamin M. LortoniD· 1 shared Daniel K. BorgeriD· 1 shared David ShechteriD· 1 shared Ellen AngelesiD· 1 shared Humaira IlyasiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Donald F. HuntORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 7, 2025

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

Alexandra Schurer, Humaira Ilyas, Maxim I. Maron…·David Shechter

This study identifies TTLL4 as a therapeutic target in NPM1-mutated AML by showing its role in stabilizing NPM1c and promoting differentiation block, with a small molecule inhibitor demonstrating efficacy.

DOI 10.1101/2025.04.07.647605

humanmouse

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BiochemistryDevelopmentPeer-reviewedOct 28, 2024

The protamines of the noble false widow spider Steatoda nobilis provide an example of liquid-liquid phase separation chromatin transitions during spermiogenesis

Melissa R. Leyden, Peter Michalik, Luciana Baruffaldi…·Juan Ausió

This paper characterizes protamines in the noble false widow spider Steatoda nobilis, revealing liquid-liquid phase separation during spermiogenesis and evolutionary links to histone H1.

2 citations

mouseproteomics

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