Author

Benjamin M. Lorton

Albert Einstein College of MedicineORCID 0000-0002-8553-2078Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

David ShechteriD· 3 shared Subray S. HegdeiD· 3 shared Donald F. HuntiD· 2 shared Jeffrey ShabanowitziD· 2 shared Maxim I. MaroniD· 2 shared Simone SidoliiD· 2 shared Alexandra SchureriD· 1 shared Daniel GroomiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

David ShechterORCID

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Author profile →

3 papers

Recent·Most cited

The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis

Isaac Kraz, Oi Wei Mak, Subray Hegde, Benjamin M. Lorton, Harrison Hector, Michael K. Broussalian, Sarah Graff, Jennifer T. Aguilan, J.B. Bonanno, Roozbeh Eskandari, Daniel Groom, Simone Sidoli, Steven C. Almo, Michael D. Brenowitz, Evripidis Gavathiotis, , David Shechter

This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.

bioRxiv · May 29, 2026 · PreprintBiochemistry

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

Alexandra Schurer, Humaira Ilyas, Maxim I. Maron, Subray S. Hegde, Melissa R. Leyden, Irene Mariam Roy, Rotila Hyka, Lucas Dada, Jeffrey Shabanowitz, Donald F. Hunt, Ellen Angeles, Victor Morell, Benjamin M. Lorton, Shira G. Glushakow-Smith, Daniel K. Borger, , David Shechter

This study identifies TTLL4 as a therapeutic target in NPM1-mutated AML by showing its role in stabilizing NPM1c and promoting differentiation block, with a small molecule inhibitor demonstrating efficacy.

bioRxiv · Apr 7, 2025 · PreprintCancer Biology

Transcriptomic and proteomic regulation through abundant, dynamic, and independent arginine methylation by Type I and Type II PRMTs

Maxim I. Maron, Stephanie M. Lehman, Sitaram Gayatri, Joseph D. DeAngelo, Subray S. Hegde, Benjamin M. Lorton, Yan Sun, Dina L. Bai, Simone Sidoli, Varun Gupta, Matthew R. Marunde, James R. Bone, Zu‐Wen Sun, Mark T. Bedford, Jeffrey Shabanowitz, , David Shechter

The paper investigates the substrate preferences and functional consequences of Type I and II PRMTs by inhibiting them in A549 cells and analyzing proteomic and transcriptomic changes.

iScience · Aug 11, 2021Peer-reviewedMolecular Biology