Laurene Abjean

The paper uses spatial transcriptomics and proteomics to show that Alzheimer's disease inflammation peaks in white matter, driven by lipid and carbonyl stress, and is linked to cognitive decline.

This study shows that TSPO knockout prevents hippocampal network dysfunctions in 3xTgAD mice without affecting amyloid or tau levels.

The paper examines microglial, inflammatory, and oligodendrocyte dynamics in Alzheimer's disease stages, finding early neuroinflammation impairs oligodendrocytes while late stages show partial recovery.

This study investigates the effects of repeated low-intensity focused ultrasound (LiFUS) with microbubbles on microglial profiles in a rat model of Alzheimer's disease, finding both short-term and long-term changes in inflammation and amyloid levels.

This study identifies cell type-specific immune alterations in bipolar disorder brains, showing reduced proinflammatory microglia and metabolic/immune dysregulation in astrocytes.

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.