Carbonyl stress primes the metastable aging brain for Alzheimer's disease
Aurélien M. Badina, Eleonore Raveloson, Isabel Meister, Quentin Amossé, Laurene Abjean, Kelly Ceyzériat, Stergios Tsartsalis, Serge Rudaz, P. Millet, Benjamin B. Tournier
The paper uses spatial transcriptomics and proteomics to show that Alzheimer's disease inflammation peaks in white matter, driven by lipid and carbonyl stress, and is linked to cognitive decline.
bioRxiv · Jul 28, 2026 · PreprintNeuroscience