Author

Marika Mearelli

German Center for Neurodegenerative DiseasesORCID 0009-0006-5168-3130Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Organism:rat· 1

Frequent Co-Authors

Carmela GiachinoiD· 2 shared Michela DeleidiiD· 2 shared Alexei VerkhratskyiD· 1 shared Bianca MarchettiiD· 1 shared Carlos MatuteiD· 1 shared Carmen FalconeiD· 1 shared Cataldo TiroloiD· 1 shared Caterina CianiiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Carmela GiachinoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceGliaPeer-reviewedSep 1, 2025

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC- Derived Microglia and Modulates Glial-Neuronal Crosstalk

Marika Mearelli, Insa Hirschberg, Christin Weissleder…·Michela Deleidi

This study investigates how C9orf72 repeat expansion affects metabolism in human iPSC-derived microglia and its impact on glial-neuronal interactions in ALS.

3 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintMar 17, 2025

Varicose-projection astrocytes: a reactive phenotype associated with neuropathology

Caterina Ciani, Giulio Pistorio, Simona Giancola…·Carmen Falcone

This study identifies varicose projection astrocytes as a reactive phenotype associated with neuropathology, showing their presence in humans, mice, and tigers and their induction by inflammation.

5 citations

humanmouse

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NeurosciencebioRxivPreprintSep 1, 2022

LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION

Carmela Giachino, Cataldo Tirolo, Salvatore Caniglia…·Bianca Marchetti

This study shows that LRRK2 G2019S mutation interacts with low-grade inflammation and aging to promote gut and peripheral immune activation before nigrostriatal degeneration in mice.

3 citations

mouseexperimental assay

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