LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION
Carmela Giachino, Cataldo Tirolo, Salvatore Caniglia, Maria Francesca Serapide, Francesca L’Episcopo, Federico Bertoli, Claudio Giuliano, Marika Mearelli, Meike Jakobi, Nicole Schneiderhan‐Marra, Michela Deleidi, Bianca Marchetti
This study shows that LRRK2 G2019S mutation interacts with low-grade inflammation and aging to promote gut and peripheral immune activation before nigrostriatal degeneration in mice.
bioRxiv · Sep 1, 2022 · PreprintNeuroscience