Author

Insa Hirschberg

German Center for Neurodegenerative Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Christin WeisslederiD· 2 shared Maria Jose Perez J.iD· 2 shared Michela DeleidiiD· 2 shared Alicia Lam· 1 shared Carmela GiachinoiD· 1 shared Cátia IgrejaiD· 1 shared Dario BrunettiiD· 1 shared Eugene ValkoviD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersNeuroscience

Christin WeisslederORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC- Derived Microglia and Modulates Glial-Neuronal Crosstalk

Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, Maria Jose Perez J., Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Paola Corti, Michela Deleidi

This study investigates how C9orf72 repeat expansion affects metabolism in human iPSC-derived microglia and its impact on glial-neuronal interactions in ALS.

Glia · Sep 1, 2025Peer-reviewedNeuroscience

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence

Maria Jose Perez J., Alicia Lam, Christin Weissleder, Federico Bertoli, Hariam Raji, Mariella Bosch, Ivan Nemazanyy, Stefanie Kalb, Mohammed Kehili, Insa Hirschberg, Dario Brunetti, Indra Heckenbach, Morten Scheibye‐Knudsen, Michela Deleidi

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

bioRxiv · Sep 3, 2024 · PreprintNeuroscience

DAP5 enables translation re-initiation on structured messenger RNAs

Ramona Weber, Leon Kleemann, Insa Hirschberg, Min-Yi Chung, Eugene Valkov, Cátia Igreja

This study identifies DAP5 as a factor enabling re-initiation of translation on structured mRNAs with uORFs, particularly for signalling factors.

bioRxiv · Jan 21, 2021 · PreprintMolecular Biology