Author

Luke Homfeldt

Boston Children's HospitalORCID 0009-0006-7164-784XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Suneet AgarwaliD· 2 shared William P. MannherziD· 2 shared Basheer BecerraiD· 1 shared Daniel E. BaueriD· 1 shared Gue‐Ho HwangiD· 1 shared Luca PinelloiD· 1 shared Noah M. Lampl· 1 shared Nozomu KawashimaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Suneet AgarwalORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanism

William P. Mannherz, Luke Homfeldt, Noah M. Lampl, Suneet Agarwal

The paper functionally analyzes TERC variants to redefine the human telomerase reverse transcription mechanism, revealing eight templating residues and a hyperactive variant that lengthens telomeres.

bioRxiv · Jun 4, 2026 · PreprintMolecular Biology

In cellulo DNA assembly for targeted genomic integration and rearrangement in human cells

Sébastien Levesque, Nozomu Kawashima, Gue‐Ho Hwang, Basheer Becerra, Vivien A. C. Schoonenberg, William P. Mannherz, Luke Homfeldt, Luca Pinello, Suneet Agarwal, Daniel E. Bauer

This paper introduces a method for targeted genomic integration and rearrangement in human cells using CRISPR-targeted dual flap synthesis, enabling DNA sequence assembly without requiring double-stranded DNA donors or cell cycle progression.

bioRxiv · Jun 16, 2025 · PreprintMolecular Biology