Author

Anuradha F. Lingappa

ORCID 0009-0006-8976-4382Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Debendranath DeyiD· 3 shared Dennis Solas· 3 shared Maya MichoniD· 3 shared Vishwanath R. LingappaiD· 3 shared Carsten KorthiD· 2 shared Jeffrey RosenfeldiD· 2 shared Justin K. IchidaiD· 2 shared Kim A. StaatsiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

Debendranath DeyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PhysiologyClinical ProteomicsPeer-reviewedApr 28, 2025

An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics

Shao Feng Yu, Maya Michon, Anuradha F. Lingappa…·Vishwanath R. Lingappa

The paper identifies a multi-protein complex in PBMCs as a target for ALS therapeutic assembly modulators, showing altered composition in ALS patients and responsiveness to treatment.

4 citations

humanproteomics

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BiochemistrybioRxivPreprintFeb 28, 2025

Small Molecule Disruption of a Protein Disulfide Isomerase-Containing Multi-Protein Complex Causes Broad Cancer Selective Metabolic Collapse and Tumor Inhibition in vivo

Anuradha F. Lingappa, Suguna Mallesh, Maya Michon…·Stevan Pecic

PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.

1 citation

mousehuman

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NeuroscienceJournal of Experimental NeurologyPeer-reviewedJan 1, 2024

Protein Assembly Modulation: A New Approach to ALS Therapeutics

Shao Feng Yu, Kumar Paulvannan, Dennis Solas…·Jeffrey Rosenfeld

This paper introduces a new drug-like small molecule series targeting PDI in a multi-protein complex for ALS treatment, showing activity in cellular and animal models.

5 citations

humanmouse

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