Author

Suguna Mallesh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Carsten KorthiD· 3 shared Debendranath DeyiD· 3 shared Dennis Solas· 3 shared Vishwanath R. LingappaiD· 3 shared Anuradha F. LingappaiD· 2 shared M. Dharma Prasad· 2 shared Maya MichoniD· 2 shared Verian BaderiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Carsten KorthORCID

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Author profile →

3 papers

Recent·Most cited

Oxidized MIF is an Alzheimer's Disease drug target relaying external risk factors to tau pathology

Andreas Müller-Schiffmann, Felix Torres, Anatoliy Kitaygorodskyy, Anand Ramani, Argyro Alatza, Sarah K. Tschirner, Julien Orts, Arthur Haltrich, Ingrid Prikulis, Shaofeng Yu, Debendranath Dey, Suguna Mallesh, Dharma Prasad, Dennis Solas, Verian Bader, , Carsten Korth

The paper identifies oxidized MIF as a drug target that links HSV-1 infection and external stressors to tau pathology in Alzheimer's disease.

Cell Reports Medicine · Dec 19, 2025Peer-reviewedNeuroscience

Small Molecule Disruption of a Protein Disulfide Isomerase-Containing Multi-Protein Complex Causes Broad Cancer Selective Metabolic Collapse and Tumor Inhibition in vivo

Anuradha F. Lingappa, Suguna Mallesh, Maya Michon, D. SHIVARUDRASWAMY, Jim Jung‐Ching Lin, M. Dharma Prasad, Debendranath Dey, Dennis Solas, Vishwanath R. Lingappa, Andreas Mueller-Schiffmann, David Andrews, Carsten Korth, Stevan Pecic

PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.

bioRxiv · Feb 28, 2025 · PreprintBiochemistry

Protein Assembly Modulation: A New Approach to ALS Therapeutics

Shao Feng Yu, Kumar Paulvannan, Dennis Solas, Anuradha F. Lingappa, Ana Raquel Moreira, Shriya Sahu, Maya Michon, Amanda Macieik, Danielle Goldsmith, Nicholas DeYarman, Suguna Mallesh, M. Dharma Prasad, Claudia Maios, Kai Ruan, Giulio Srubek Tomassy, , Jeffrey Rosenfeld

This paper introduces a new drug-like small molecule series targeting PDI in a multi-protein complex for ALS treatment, showing activity in cellular and animal models.

Journal of Experimental Neurology · Jan 1, 2024Peer-reviewedNeuroscience