Protein Assembly Modulation: A New Approach to ALS Therapeutics
Shao Feng Yu, Kumar Paulvannan, Dennis Solas, Anuradha F. Lingappa, Ana Raquel Moreira, Shriya Sahu, Maya Michon, Amanda Macieik, Danielle Goldsmith, Nicholas DeYarman, Suguna Mallesh, M. Dharma Prasad, Claudia Maios, Kai Ruan, Giulio Srubek Tomassy, , Jeffrey Rosenfeld
This paper introduces a new drug-like small molecule series targeting PDI in a multi-protein complex for ALS treatment, showing activity in cellular and animal models.
Journal of Experimental Neurology · Jan 1, 2024Peer-reviewedNeuroscience