Carsten Korth

The paper identifies oxidized MIF as a drug target that links HSV-1 infection and external stressors to tau pathology in Alzheimer's disease.

PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.

This paper introduces a new drug-like small molecule series targeting PDI in a multi-protein complex for ALS treatment, showing activity in cellular and animal models.

This study uses iPSC-derived neuronal cultures with the TREM2 R47H variant to construct an Aβ-induced gene regulatory network, identifying ER-stress as a potential causal factor in LOAD.