Author

Léa Schlunke

École Polytechnique Fédérale de LausanneORCID 0009-0007-1394-0842Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Gauri PadutholiD· 2 shared John D. McKinneyiD· 2 shared Kathrin TomasekiD· 2 shared Valentin BorgeatiD· 2 shared Allison M. BurnsiD· 1 shared Christian PasqualiiD· 1 shared Giovanna AmbrosiniiD· 1 shared Graham William KnottiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

Gauri PadutholORCID

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2 papers

Recent·Most cited

BioengineeringNature CommunicationsPeer-reviewedFeb 3, 2026

A bioengineered human urothelial organoid model reveals the urine-urothelium interplay in tissue resilience and UPEC recurrence in urinary tract infections

Gauri Paduthol, Mikhail Nikolaev, Kunal Sharma…·John D. McKinney

The paper develops a human urothelial organoid model to study urine-urothelium interactions in UTI resilience and UPEC recurrence, finding that high-solute urine weakens tissue and promotes CWD UPEC formation.

6 citationstop 1%

humanorganoid / primary culture

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MicrobiologybioRxivPreprintOct 22, 2025

Lysosomal activation in bladder epithelium enhances intracellular antibiotic clearance of uropathogenic Escherichia coli

Kathrin Tomasek, Kristina Skurvydaite, Gauri Paduthol…·John D. McKinney

This study shows that OM-89 enhances lysosomal activity in bladder epithelial cells, improving antibiotic efficacy against UPEC and reducing bacterial regrowth.

DOI 10.1101/2025.10.22.683857

mousehuman

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