Author

Gauri Paduthol

École Polytechnique Fédérale de LausanneORCID 0000-0002-6654-3281Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

John D. McKinneyiD· 2 shared Kathrin TomasekiD· 2 shared Léa SchlunkeiD· 2 shared Valentin BorgeatiD· 2 shared Allison M. BurnsiD· 1 shared Christian PasqualiiD· 1 shared Giovanna AmbrosiniiD· 1 shared Graham William KnottiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

John D. McKinneyORCID

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2 papers

Recent·Most cited

A bioengineered human urothelial organoid model reveals the urine-urothelium interplay in tissue resilience and UPEC recurrence in urinary tract infections

Gauri Paduthol, Mikhail Nikolaev, Kunal Sharma, Jérôme Blanc, Kathrin Tomasek, Léa Schlunke, Valentin Borgeat, Giovanna Ambrosini, Irina Kolotuev, Stéphanie Clerc-Rosset, Nikolche Gjorevski, Graham William Knott, Matthias P. Lütolf, Vivek V. Thacker, John D. McKinney

The paper develops a human urothelial organoid model to study urine-urothelium interactions in UTI resilience and UPEC recurrence, finding that high-solute urine weakens tissue and promotes CWD UPEC formation.

Nature Communications · Feb 3, 2026Peer-reviewedBioengineering

Lysosomal activation in bladder epithelium enhances intracellular antibiotic clearance of uropathogenic Escherichia coli

Kathrin Tomasek, Kristina Skurvydaite, Gauri Paduthol, Allison M. Burns, Léa Schlunke, Valentin Borgeat, Christian Pasquali, Mario Romani, John D. McKinney

This study shows that OM-89 enhances lysosomal activity in bladder epithelial cells, improving antibiotic efficacy against UPEC and reducing bacterial regrowth.

bioRxiv · Oct 22, 2025 · PreprintMicrobiology