Jennifer R. Chao

Nutrient Microenvironments Reprogram Pigment Epithelium Metabolism and Phenotype

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

In vivo elastography of the human retina using light-evoked intrinsic actuation

This paper introduces a method to measure retinal biomechanics in vivo using light-evoked intrinsic actuation and optical coherence tomography, revealing deformation patterns in retinal compartments and detecting functional changes in retinitis pigmentosa.

Metabolic phenotyping of healthy and diseased human RPE cells

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.

Reassessing Retinal Pigment Epithelial Ketogenesis: Enzymatic Assays for Ketone Body Levels Provide Inaccurate Results

This study shows that enzymatic assays overestimate β-hydroxybutyrate (β-HB) in RPE cultures, while mass spectrometry reveals equal apical and basal secretion and β-HB sources from fatty acids and amino acids.