Chance Meers

This study identifies a nitrite-responsive regulatory RNA locus in Bacteroides thetaiotaomicron that enhances resilience to nitrosative stress during intestinal inflammation.

The paper identifies a novel RNA-guided transcription mechanism using dCas12f and σE factors in E. coli, enabling gene activation without traditional promoter motifs.

This study identifies evolutionary links between bacterial IS110 transposons and archaeal/eukaryotic RNA modification systems, suggesting RNA-guided mechanisms evolved from transposon components.

The paper investigates the molecular mechanisms of transposition and RNA-guided DNA cleavage in IS607-family elements, revealing how transposon-encoded RNAs balance splicing and guide RNA functions.

The paper identifies TnpB-like nuclease-dead repressors (TldR) as RNA-guided transcription factors that emerged through domestication of transposon-encoded TnpB nucleases, pre-dating CRISPR-Cas systems.

This study examines rNMP incorporation in AGS-ortholog yeast mutants, revealing differences in rNMP abundance and strand-specific patterns.

This study shows that transposon-encoded nucleases use guide RNAs to bias transposon inheritance by cleaving donor joints formed during transposition.