A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway
Delphine Bonhomme, Hugo Vaysset, Eirene Marie Q. Ednacot, Vasco Rodrigues, Yazan Salloum, Jean Cury, Anny Wang, Axel Benchetrit, Pierre Affaticati, Veronica Hernandez Trejo, Paul Vittot, Charlie Bories, Alexis Cornec, Jean‐Pierre Levraud, Pedro P. Hernández, , Enzo Z. Poirier
The paper identifies SIRanc, a human homolog of bacterial antiphage SIR2 proteins, and shows it mediates innate immunity via the TLR pathway by degrading NAD+.
Science · Jul 24, 2025Peer-reviewedImmunology