Author

Nathan A. Schacht

University of MinnesotaORCID 0009-0007-7081-7648Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Anthony D. BaughniD· 2 shared Michael D. Howe· 2 shared Ziyi JiaiD· 2 shared Courtney C. AldrichiD· 1 shared Elise A. LamontiD· 1 shared Gebremichal GebretsadikiD· 1 shared Lev OstreriD· 1 shared Muzafar Ahmad RatheriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Anthony D. BaughnORCID

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2 papers

Recent·Most cited

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedDec 19, 2025

Essential Role of MHC II in the Antitubercular Efficacy of Pyrazinamide

Elise A. Lamont, Shannon Lynn Kordus, Michael D. Howe…·Anthony D. Baughn

This study shows that MHC II and CD4 T cell help are essential for pyrazinamide's antitubercular efficacy, revealing a host-mediated mechanism for its in vivo activity.

DOI 10.1128/aac.01264-25

mousebulk RNA-seq

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MicrobiologyPNAS NexusPeer-reviewedJul 29, 2025

Mechanism of the Dual Action Self-Potentiating Antitubercular Drug Morphazinamide

Lev Ostrer, Taylor A. Crooks, Michael D. Howe…·Anthony D. Baughn

This study identifies a dual mechanism of action for morphazinamide, a more potent pyrazinamide analog, showing it kills Mycobacterium tuberculosis through coenzyme A disruption and aldehyde release, which also bypasses resistance.

3 citations

humanmouse

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