Colin Henchy

The paper investigates how MYC and RNA polymerase II binding near transcriptional end sites (TESs) regulates gene expression and read-through transcription in human and murine cells.

The paper shows that dissociation of mitochondrial Complex V into Fo and F1 domains balances anabolic and energy needs in cancer cells by uncoupling ATP synthesis from TCA cycle activity.

This paper describes the generation of genetically-defined murine hepatoblastoma cell lines with angiogenic potential and reports their tumorigenic properties and drug sensitivities.

This paper describes the generation of isogenic murine hepatoblastoma cell lines with defined oncogenic drivers, which retain tumorigenicity and express endothelial markers under hypoxic conditions.

The paper identifies Gas1 as a suppressor of hepatoblastoma tumorigenesis by showing its restoration inhibits tumor growth in mice and cell lines, and identifies a common set of B-Y-N regulated genes.