Edward V. Prochownik

MYC and RNA Polymerase II Binding Near Transcriptional End Sites Regulate the Expression of Functionally-Related Genes

The paper investigates how MYC and RNA polymerase II binding near transcriptional end sites (TESs) regulates gene expression and read-through transcription in human and murine cells.

Reversible Dissociation of Mitochondrial Complex V Balances Anabolic and Energy-Generating Needs in Cancer

The paper shows that dissociation of mitochondrial Complex V into Fo and F1 domains balances anabolic and energy needs in cancer cells by uncoupling ATP synthesis from TCA cycle activity.

Derivation of Genetically-Defined Murine Hepatoblastoma Cell Lines with Angiogenic Potential

This paper describes the generation of genetically-defined murine hepatoblastoma cell lines with angiogenic potential and reports their tumorigenic properties and drug sensitivities.

Efficient Derivation of Immortalized, Isogenic Cell Lines from Genetically Defined Murine Hepatoblastomas

This paper describes the generation of isogenic murine hepatoblastoma cell lines with defined oncogenic drivers, which retain tumorigenicity and express endothelial markers under hypoxic conditions.

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read-Through Transcription and Intragenic Contacts

This study identifies MYC and MAX binding near transcriptional end sites (TESs) and shows their role in regulating gene expression, read-through transcription, and intragenic contacts.

Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis

The paper identifies Gas1 as a suppressor of hepatoblastoma tumorigenesis by showing its restoration inhibits tumor growth in mice and cell lines, and identifies a common set of B-Y-N regulated genes.