Author

Rama Aldakhlallah

Scripps Research InstituteORCID 0009-0008-5833-0244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

Danielle Ann GrotjahniD· 2 shared Mashiat ZamaniD· 2 shared Prakhyat MathuriD· 2 shared Prerona BoraiD· 2 shared R. Luke WisemaniD· 2 shared Samantha OviedoiD· 2 shared Sophia Krasny· 2 shared Timothy E. ShuttiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersCell Biology

Danielle Ann GrotjahnORCID

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2 papers

Recent·Most cited

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedNov 25, 2025

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells

Prerona Bora, Mashiat Zaman, Samantha Oviedo…·R. Luke Wiseman

The paper identifies two compounds that activate the HRI pathway, improving mitochondrial function in MFN2-deficient cells.

10 citations

humanproteomics

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Cell BiologyeLifePeer-reviewedSep 25, 2024

Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation

Kelsey R Baron, Samantha Oviedo, Sophia Krasny…·R. Luke Wiseman

This study shows that pharmacologic activation of ISR kinases HRI or GCN2 prevents mitochondrial fragmentation in disease models.

18 citations

humanproteomics

𝕏 PostBluesky