Author

Prakhyat Mathur

Scripps Research InstituteORCID 0000-0002-3129-4465Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

Danielle Ann GrotjahniD· 2 shared Mashiat ZamaniD· 2 shared Prerona BoraiD· 2 shared R. Luke WisemaniD· 2 shared Rama AldakhlallahiD· 2 shared Samantha OviedoiD· 2 shared Sophia Krasny· 2 shared Timothy E. ShuttiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersCell Biology

Danielle Ann GrotjahnORCID

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2 papers

Recent·Most cited

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells

Prerona Bora, Mashiat Zaman, Samantha Oviedo, Sergei Kutseikin, Nicole Madrazo, Prakhyat Mathur, Meera Pannikkat, Sophia Krasny, Rama Aldakhlallah, Alan Chu, Kristen A. Johnson, Danielle Ann Grotjahn, Timothy E. Shutt, R. Luke Wiseman

The paper identifies two compounds that activate the HRI pathway, improving mitochondrial function in MFN2-deficient cells.

Proceedings of the National Academy of Sciences · Nov 25, 2025Peer-reviewedCell Biology

Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation

Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Prerona Bora, Prakhyat Mathur, Gerald Pfeffer, Michael J. Bollong, Timothy E. Shutt, Danielle Ann Grotjahn, R. Luke Wiseman

This study shows that pharmacologic activation of ISR kinases HRI or GCN2 prevents mitochondrial fragmentation in disease models.

eLife · Sep 25, 2024Peer-reviewedCell Biology