Author

Sophia Krasny

Scripps Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

Danielle Ann GrotjahniD· 2 shared Mashiat ZamaniD· 2 shared Prakhyat MathuriD· 2 shared Prerona BoraiD· 2 shared R. Luke WisemaniD· 2 shared Rama AldakhlallahiD· 2 shared Samantha OviedoiD· 2 shared Timothy E. ShuttiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersCell Biology

Danielle Ann GrotjahnORCID

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Author profile →

2 papers

Recent·Most cited

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells

Prerona Bora, Mashiat Zaman, Samantha Oviedo, Sergei Kutseikin, Nicole Madrazo, Prakhyat Mathur, Meera Pannikkat, Sophia Krasny, Rama Aldakhlallah, Alan Chu, Kristen A. Johnson, Danielle Ann Grotjahn, Timothy E. Shutt, R. Luke Wiseman

The paper identifies two compounds that activate the HRI pathway, improving mitochondrial function in MFN2-deficient cells.

Proceedings of the National Academy of Sciences · Nov 25, 2025Peer-reviewedCell Biology

Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation

Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Prerona Bora, Prakhyat Mathur, Gerald Pfeffer, Michael J. Bollong, Timothy E. Shutt, Danielle Ann Grotjahn, R. Luke Wiseman

This study shows that pharmacologic activation of ISR kinases HRI or GCN2 prevents mitochondrial fragmentation in disease models.

eLife · Sep 25, 2024Peer-reviewedCell Biology