Giorgia Mazzini

This paper develops a dynamic suspension culture system to improve the maturation of hiPSC-derived cartilage organoids, showing enhanced ECM deposition and gene expression compared to static culture.

This study evaluates iopanoic acid's therapeutic effects on osteoarthritis using mouse models and human tissue explants, showing reduced cartilage degradation and improved repair.

The paper maps chondrogenic cell-fate trajectories in hiPSCs using scRNA-seq and scATAC-seq, identifying NFIA and NFIB as key regulators driving chondrogenic commitment.