Structure, dynamics, and processing of 8oxoG:A in the nucleosome
Abigayle F. Vito, Justin A. Ling, Julia C. Ferrara, Caleb S Jacques, Natacha Gillet, Roy González‐Alemán, Yuya Qiu, Mohammad Hashemian, Carlos H. Trasviña‐Arenas, Sheila S. David, Sarah Delaney, Emmanuelle Bignon, Bret Freudenthal
This study determines the structure and dynamics of 8oxoG:C and 8oxoG:A base pairs in the nucleosome and characterizes MUTYH activity, revealing that 8oxoG:A is less processable by MUTYH.
bioRxiv · Sep 2, 2025 · PreprintBiochemistry