Author

Natacha Gillet

École Normale Supérieure de LyonORCID 0000-0002-7657-6861Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Natacha Gillet1 paper

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Emmanuelle BignoniD· 2 shared Abigayle F. VitoiD· 1 shared Alan E. TomkinsoniD· 1 shared Amy M. WhitakeriD· 1 shared Ashlee G Nguyen· 1 shared Bennett Van HouteniD· 1 shared Bret FreudenthaliD· 1 shared Caleb S JacquesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Emmanuelle BignonORCID

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2 papers

Recent·Most cited

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

Daniel J. Boesch, Nadia I Martin, Chantal A Kontor, Ashlee G Nguyen, Alan E. Tomkinson, Bennett Van Houten, Natacha Gillet, Emmanuelle Bignon, Amy M. Whitaker, Tyler Weaver

This study investigates how DNA Ligase IIIα ligates nicks in nucleosomes using biochemical assays, molecular dynamics, and cryo-EM, revealing position-dependent efficiency and structural constraints.

Nature Communications · Sep 2, 2026Peer-reviewedBiochemistry

Structure, dynamics, and processing of 8oxoG:A in the nucleosome

Abigayle F. Vito, Justin A. Ling, Julia C. Ferrara, Caleb S Jacques, Natacha Gillet, Roy González‐Alemán, Yuya Qiu, Mohammad Hashemian, Carlos H. Trasviña‐Arenas, Sheila S. David, Sarah Delaney, Emmanuelle Bignon, Bret Freudenthal

This study determines the structure and dynamics of 8oxoG:C and 8oxoG:A base pairs in the nucleosome and characterizes MUTYH activity, revealing that 8oxoG:A is less processable by MUTYH.

bioRxiv · Sep 2, 2025 · PreprintBiochemistry