Daniel B. Longley

This study identifies FLIP as a critical survival factor in KRAS-mutant lung cancers, revealing a KRAS-ERK-FLIP axis that protects against apoptosis and suggests FLIP as a therapeutic target.

The paper investigates cell engulfment in colorectal cancer, showing it creates competitive metabolic niches linked to clinical outcomes.

This study shows that poly(I:C) treatment in CMS4 colorectal tumors induces a pro-inflammatory, CMS1-like regenerative state and identifies biomarkers for predicting therapeutic response.

This paper identifies a five-protein stem cell signature using a deep neural network that predicts relapse in stage III colorectal cancer patients.

This study shows Mcl-1 accumulation and redistribution during the cell cycle increase MOMP thresholds, contributing to cell-to-cell variability in apoptosis susceptibility and intra-tumour heterogeneity.

This study uses high-resolution spatial proteomics to characterize colorectal cancer consensus molecular subtypes at single-cell resolution, revealing subtype-specific immune and metabolic features.

The paper investigates the spatial relationship between T cells and cancer cells in stage III CRC patients, finding that closer proximity of T cells to cancer cells is associated with better disease-free survival.