Author

Shaun Sharkey

Queen's University Belfast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Connor N. BrowniD· 2 shared Emma M. KerriD· 2 shared Matilda Downs· 2 shared A.R. Phillips· 1 shared Aaron Philips· 1 shared Aideen E. RyaniD· 1 shared Aisling Y. CoughlaniD· 1 shared Alexandra J Emerson· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Connor N. BrownORCID

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2 papers

Recent·Most cited

FLIP is essential for oncogenic KRAS-driven lung cancer

Claudia Hamilton, Shaun Sharkey, Hajrah A. Khawaja, Matilda Downs, Christopher McLaughlin, Connor N. Brown, Declan F. Doherty, Jennifer Fox, Mihaela Pettigrew, Karl T. Butterworth, A.R. Phillips, Donna M. Small, Timothy Harrison, Catherine A. Higgins, Emma M. Kerr, Daniel B. Longley

This study identifies FLIP as a critical survival factor in KRAS-mutant lung cancers, revealing a KRAS-ERK-FLIP axis that protects against apoptosis and suggests FLIP as a therapeutic target.

bioRxiv · Aug 5, 2026 · PreprintCancer Biology

Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw, Chris McCann, Nikita Lewis, Matilda Downs, Rebecca Wurelly, Ciara Cunningham, Aaron Philips, Niamh Doherty, Sarah Gallagher, William J. McDaid, Andrew J. Roe, Aisling Y. Coughlan, Brenton Cavanagh, , Emma M. Kerr

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

Nature Metabolism · Jul 23, 2026Peer-reviewedCancer Biology